Overview

This paper reports Phase 1 of the EXCEL (Exercise for Cognitive Health) study. It presents the development of an evidence-informed model of mechanisms of action (MoAs) for physical activity interventions targeting people in mid- to later-life experiencing cognitive concerns alongside symptoms of depression or anxiety. Using a qualitative design that triangulated data from semi-structured interviews with 21 participants, a critical review of 24 published studies, and the Capability, Opportunity and Motivation Behaviour (COM-B) framework, the study identifies the key factors influencing physical activity engagement in this at-risk population. The resulting model provides specificity, directionality and linked behaviour change approaches for intervention tailoring to optimise dementia risk reduction. Findings from this model directly informed the design of the EXCEL Phase 2 intervention (Ellis et al. 2026).

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Key insights

This study is the first to develop a targeted, evidence-informed model of the mechanisms through which physical activity interventions can effectively support behaviour change in people aged 45 and older who live with both cognitive concerns and symptoms of depression or anxiety. By triangulating participant lived experience, published evidence and behavioural science theory, the model identifies five key areas for intervention tailoring — knowledge, attitudes, self-regulation skills, social opportunities, and access to flexible resources — with emotional regulation emerging as a uniquely critical and previously under-emphasised factor for this population.

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How can this resource help me as a...?

This qualitative study and model development paper is directly relevant to researchers working in dementia prevention, physical activity behaviour change, mental health, and complex intervention design. It provides a replicable methodological approach and a theoretically grounded model that can inform future research in this and related populations.

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